The Bench to Bassinet Program is a major effort launched by the National Heart,
Lung, and Blood Institute to learn more about how the heart develops and why children
are born with heart problems. This information will be used to develop new ways to
help infants, children, teenagers, and adults born with heart disease.
OUR MISSION: The Bench to Bassinet's mission is to accelerate
scientific discovery to clinical practice by fostering collaborations of basic,
translational and clinical researchers through a flexible program designed to improve
outcomes for individuals with congenital heart disease while supporting the needs
of the pediatric heart disease research community.
Pediatric Academic Societies Honors Bill Pu
The B2B congratulates William Pu on receipt of the E. Mead Johnson Award for
Research in Pediatrics at the recent annual meeting of the Pediatric Academic
Societies. This prestigious award honors outstanding clinical and laboratory
research achievements in pediatrics. Dr. Pu presented a talk at the meeting
titled "Modeling Cardiomyopathy Using Human Induced Pluripotent Stem Cells".
New features and datasets have been added to the
For Researchers pages.
(1) A database is now available of all mouse ENU mutations detected through
whole-exome sequencing of mouse lines screened for congenital heart defects.
The database is searchable by gene,
mouse line, and phenotype.
(2) CvDC datasets have been organized by Topic on the
Datasets page and links
are provided to the related Topic in the CvDC Data Repository.
(3) The Bioinformatics Tools page
provides links to three novel tools developed within the CvDC.
The Pediatric Cardiac Genomics Consortium launches its prospective cohort study
|Subjects Enrolled: 5,922|
Relatives Enrolled: 7,650
Spontaneous Mutations Cause Some Congenital CHD
The PCGC investigators recently reported findings from the first
large-scale sequencing analysis of congenital heart disease.
The results of this study suggest that at least 10% of cases
result from genetic mutations that weren't inherited from their parents.
The analysis found that spontaneous, or de novo, mutations affect a
specific biological pathway that is critical to aspects of human
development, including the brain and heart. Read the complete article in
Nature, and highlights in the
press release and at
NIH Research Matters, and a recent
Wall Street Journal article (subscription required).
The Congenital Heart Disease Genetic Network Study
Investigators from several leading U.S. medical schools, supported
by the NHLBI, initiated the Congenital Heart Disease Genetic Network Study
(abbreviated CHD GENES) in 2011. The study is using state-of-the-art
DNA analyses to uncover the genetic causes of heart defects with which
children are born. The early results in recruitment and banking of DNAs
have been highly successful. Read the complete
in the February 15, 2013 issue of Circulation Research.
Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment
MIT investigators have discovered a long non-coding RNA (lncRNA) that is
critical for the in vitro differentiation of embryonic stem cells toward
the cardiovascular lineage. These findings provide the basis for the
identification of a new class of molecules that regulate cardiac transcriptional
networks and for achieving a greater understanding of heart development. Read the complete
in the January 2013 issue of Cell.